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Theexamples are meant to illustrate the following principles:(i) some chemicals are selective nephrotoxicants by virtueof the existence of specific transporters that efficientlydeliver the chemicals to their target cell; (ii) some chemicalselicit nephrotoxicity after uptake and accumulation in renalcells because of the presence of bioactivation enzymes inthe cell; (iii) the mechanism of nephrotoxicity of manychemicals involves effects on specific subcellular organ-elles (e.g., mitochondria, lysosomes); and (iv) manychemicals can elicit a range of diverse effects in renalcells. Additionally, many pat-terns frequently encountered in the ICU do not fulfill classic seizure definitions and arecharacterized by the term “ictal-interictal continuum” (8)

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